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2007-9-2 10:10:36

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Grape seed extract (GSE) with high levels of polyphenols may help protect cardiac cells against an apoptosis increasing production of endogenous antioxidant enzymes, according to a new laboratory study by Chinese researchers.

Early studies have demonstrated that GSE has protective effects on various forms of cardiac disorders, but it remains unknown how GSE affects on cardiac disorders.


The current study published in the march 7 2007 issue of Journal of Agricultural and Food Chemistry was meant to examine the effects of polyphenols found in GSE namely catechin and proanthocyanidin B4 on endogenous antioxidant enzymes in cardiomyocytes and if any how they affects oxidative cardiac cell injury.


Hongxiang Lou and colleagues from Shandong University, China found that incubation of cardiac H9C1 cells with catechin or proanthocyanidin B4 significantly induced cellular antioxidant enzymes in a dose responsive matter.

Additionally, pretreatment of cardiac cells with catechin or proanthocyanidin B4 pretreatment led to a significant reduction in xanthine oxidase(XO)/xanthine-induced intracellular reactive oxygen species (ROS) accumulation and cardiac cell apoptosis.


Lou and team concluded that grape seed polyphenols may protect against cardiac cell apoptosis by inducing production of endogenous antioxidant enzymes. They suggested this may be the mechanism by which GSE protects various forms of cardiovascular disorders.